Depending on cumulative steroid dose and cumulative treatment time, an increased risk of diabetes between 24 and 44% was noted.
The authors concluded that “An increased risk of new-onset diabetes may be an important consideration in the treatment of patients with topical corticosteroids, especially when intense skin treatment is needed.”
van der Linden MW, et al. Topical corticosteroids and the risk of diabetes mellitus: a nested case-control study in the Netherlands.Drug Saf. 2009;32(6):527-37. doi: 10.2165/00002018-200932060-00008.